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Charlie Harper (Charlie Sheen, "Spin City") é um solteiro bem de vida que vive numa casa na praia, tem um belo carro na garagem e tem uma grande facilidade de conquistar as mulheres. Seu estilo de vida casual em Malibu é interrompido quando seu irmão Alan (Jon Cryer), que está no meio de um divórcio, e seu sobrinho de 10 anos Jake (Angus T. Jones), chegam para morar com ele.

Para complicar ainda mais as coisas, há também a obcecada e controladora mãe de Charlie e Alan, Evelyn (Holland Taylor); a afastada mulher de Alan, Judith (Marin Hinkle, "Once and Again"), que "acredita" que é gay; e a atraente e meio estranha vizinha Rose (Melanie Lynskey), que teve um breve romance com Charlie quer estar presente na vida dele custe o que custar.

Apesar desse estranho relacionamento, Charlie e Alan descobrem que ambos tem uma coisa em comum: eles amam Jake e querem o melhor para ele. Os irmãos concordam em criar um lar adequado para Jake na casa de Charlie, e juntos esses dois homens e meio encaram os desafios de (em alguns casos, finalmente) se tornarem adultos.

1ª Temporada

01 - Pilot
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02 - Big Flappy Bastards
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03 - Go East on Sunset
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04 - If I Can't Write my Chocolate Song I'm Going to Take a Nap
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05 - The Last thing you want is to wind up with a hump
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06 - Did you check with the captain of the flying monkeys?
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07 - If they do go either way they're usually Fake
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08 - Twenty-five pre-rubers without a snoot full
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09 - Phase One Complete
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10 - Merry Thanksgiving
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11 - Alan Harper Frontier chiropractor
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12- Camel Filters + pheromones
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13 - Sara Like Puny Alan
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14 - I Can't Afford Hyenas
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15 - Round one to the hot crazy chick
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16 - That Was Saliva Alan
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17- Ate the Hamburgers wearing the hats
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18- An Old Flame with a New Wick
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19 - I remember the coatroom I just don't remember you
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20 - Hey I can Pee Outside in the dark
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21 - No Sniffing, No Wowing
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22 - My doctor has a cow puppet
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23 - Just Like Buffalo
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24 - Can You Feel my Finger?
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2ª Temporada

2x01- Back Off, Mary Poppins
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2x02- Enjoy Those garlic Balls
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2x03- A Bag Full Of Jawea
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2x04- Go, Get Mommy
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2x05- Bad News From Clinic
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2x06- The Price of Health Gums is Eternal Vigilance
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2x07- A Kosher Slaughterhouse Out in Fontana
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2x08- Frankenstein and the Horny Villages
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2x09- Yes, Monsignor!
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2x10- Salmon Under My Sweater
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2x11- Last Chance to See Those Tatoos
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2x12- A Lungful of Alan
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2x13- Get Off My Hair
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2x14 - Those Big Pink Things with Coconut
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2x15 - Smell the Umbrella Stand
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2x16 - Can you Eat Human Flesh with Wooden Teeth?
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2x17 - Woo-Hoo, A Hernia-Exam!
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2x18 - It Was Mame, Mom
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2x19 - A Low, Gutteral Tongue-Flapping Noise
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2x20 - I Always Wanted a Shaved Monkey
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2x21 - A Sympathetic Crotch to Cry On
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2x22 - That Old Hose Bag Is My Mother
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2x23 - Squab, Squab, Squab, Squab, Squab
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2x24 - Does This Smell Funny to You?
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3ª Temporada

3x01 - Weekend in Bangkok with Two Olympic Gymnasts
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3x02 - Principal Gallagher's Lesbian Lover
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3x03 - Carpet Burns and a Bite Mark
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3x04 Your Dismissive Attitude Toward Boobs
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3x05 We Called it Mr. Pinky!
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3x06 Hi, Mr. Horned One!
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3x07 Sleep Tigh, Puddin" Pop.rmvb
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3x08 That Voodoo That I Do
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3x09 Madame and Her Special Friend
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3x10 Something Salted and Twisted
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3x11 Santa's Village of the Damned
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3x12 That Special Tug
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3x13 Humiliation is a Visual Medium
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3x14 Love Isn't Blind, It's Retarded
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3x15 My Tongue is Meat
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3x16 Ergo The Booty Call
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3x17 The Unfortunate Little Schnauser
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3x18 The Spit-Covered Cobbler
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3x19 Golly Moses, She's A Muffin
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3x20 Always a Bridesmaid, Never a Burro
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3x21 And the Plot Moistens
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3x22 Just Once With Aunt Sophie
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3x23 Arguments for the Quickie
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3x24 That Pistol-Packin" Hermaphrodite
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4ª Temporada

4.01 Working for Caligula
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4.02 Who's Vod Kanockers
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4.03 The Sea is a Harsh Mistress
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4.04 A Pot Smoking Monkey
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4.05 A Live Women of Proven Fertility
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4.06 Apologies for the Frivolity
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4.07 Repeated Blows to his Unformed Head
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4.08 Release the Dogs
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4.09 Corey Been Dead For an Hour
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4.10 Kissing Abraham Lincoln
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4.11 Walnuts and Demerol
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4.12 Castrating Sheep in Montana
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4.13 Don't Worry, Speed Racer!
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4.14 That's Summer Sausage, Not Salami
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4.15 My Damn Stalker
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4.16 - Young People Have Phlegm Too
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4.17 - I Merely Slept With a Commie
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4.18 - It Never Rains in Hooterville
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4.19 - Smooth as a Ken Doll
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4x20 - Aunt Myra Doesn't Pee a Lot
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4x21 - Tucked, Taped and Gorgeous
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4x22 - Mr. McGlue's Feedbag
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4x23 - Anteaters. They're Just Crazy-lookin
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4x24 - Prostitutes and Gelato
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5ª Temporada

5x01 - Large Birds, Spiders and Mom
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5x02 - Media Room Slash Dungeon
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5x03 - Dum Diddy Dum Diddy Doo
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5x04 - City of Great Racks
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5x05 - Putting Swim Fins on a Cat
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5x06 - Help Daddy Find His Toenail
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5x07 - The Leather Gear is in the Guest Room
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5x08 - Is There a Mrs. Waffles?
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5x09 - Shoes, Hats, Pickle, Jar Lids.
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5x10 - Kinda Like Necrophilia
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